Author Archives: KLG

Coffee Break: More on American Science, An NIH Grant Long Overdue, An Experimental Model, and Further Thoughts on AI

Part the First: Back to the Past in Science and Medicine.  The future of basic science in the United States looks grim for everyone from the aspiring graduate student to the full professor who has met her potential and has several graduate students, postdocs, and technicians working in her laboratory.  The precipitous and arbitrary Big […]

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A New Cancer Drug and the Nature of Scientific Discovery

Glen Campbell, who was a member of The Wrecking Crew, once remarked that he had worked hard for ten years to become an overnight success in 1967, with thanks to John Hartford.  Without stretching too much, this same trajectory, extended by more than ten years, has been illustrated recently in biomedical research by the case […]

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Coffee Break: American Science in Distress, Technology vs. Community, and the Restaurant Problem Solved

Part the First: The Sabotage of American Science.  For much of the past forty years I have been in the “business” of writing grant proposals and/or doing research that has been publicly funded by the National Institutes of Health and the National Science Foundation.  This includes work supported by the American Cancer Society (ACS) and […]

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Coffee Break: Theology at Work in the World, Eugenics Is Still Undead, Science Is Still Under Attack, and Ultra-Processed Foods in the Dock

Part the First: Pope Leo XIV and the Larger World.  Of the academic historians currently writing for both their colleagues and students and the general reader, Greg Grandin is among the finest.  In The Education of Pope Leo XIV he places the former Father Bob Prevost and current Pope Leo XIV in context of our […]

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A Food Philosophy for Our Time?

It is clear that in much of the so-called developed world, food has largely lost its meaning beyond nourishment.  Julian Baggini has written about this, ten years ago in The Virtues of the Table, which is especially useful in considering how and why we eat.  More recently Baggini has expanded his range in How the […]

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Coffee Break: Ancient Art, the Return of Analog, Science in Distress, and Death Is for Losers

Part the First: Functional Art from the Enigmatic Daunians.  William Morris famously wrote, “Have nothing in your houses that you do not know to be useful or believe to be beautiful.”  Of course, his beauty in response to the immiseration of the working class was for the English rich but nothing is perfect.  Our old […]

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Coffee Break: The Furies are Coming for US

Today’s Coffee Break on a holiday weekend in the US  is the simple recommendation that you go straight to this long essay in Front Porch Republic by W. Aaron Vandiver of Carbondale, Colorado: Trump and the Furies of Empire –– Trump, in his crude way, is forcing us to confront the false stories we have […]

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The One Big Beautiful Bill Act and Medical Education in These United States

On Independence Day of 2025 President Trump signed his One Big Beautiful Bill Act (OBBBA) into law.  Something that has not gotten much attention, so far, are the consequences OBBBA will have on students who must borrow money to attend college/university, graduate school, and/or professional school.  Should American students be forced to go into debt […]

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Coffee Break: Scientists and the Growth Economy, Sternly Worded Letters, Scientist Runs Afoul of RFKJr, Timothy Snyder with the Editor of Science, and Wither Food

Dear gentle readers: Apologies for a somewhat ragged Coffee Break today.  Traveling in Scotland and time has been taken up with details (all good) along with a few unexpected disconnects (as in stuff happens). Part the First: Scientists to the Rescue?  Economic growth is not the answer to any of our problems in this finite […]

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Coffee Break: Counterfeit Scientific Papers, Deep Fakes, CDC on the Ropes, MAHA, and Hope from the Middle of the Country

Part the First: Paper Mills and the Corruption of Research.  No not Hammermill.  I don’t think I have actually known of someone buying a “scholarly” paper for publication, and I remember reading (a few paragraphs) only a few that seemed to be purpose built.  But following up on The Credibility Crisis in Science from earlier […]

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Coffee Break: American Science in the Crosshairs, Nuclear Nightmares, and a Vision of a Good Life

Part the First: The Attack on American Science Continues, Unabated.  A few days ago the president fired the National Science Board (NSB), all twenty-two members of a statutory twenty-five, who served staggered six-year terms that preserved institutional memory.  The NSB was created pursuant to the National Science Foundation Act of 1950 to “recommend and encourage […]

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Coffee Break: Alzheimer’s Disease Still a Mystery and Books Worth Reading

Part the First: Anti-amyloid Antibodies and Alzheimer’s Disease (AD).  A Cochrane review of monoclonal antibodies targeting amyloid plaques in AD has found that these drugs have little to no effect on cognitive function of AD patients.  Cochrane reviews are, to use one of the favorite tropes of the current administration, considered the “gold standard” of […]

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Coffee Break: Scientists Being Bad and Good, the Moon, and More Ancient Archaeology

Part the First: Dealing with Scientific Misconduct.  Trust in science has declined during my professional work life.  Some, but not all, of this is due to misconduct by scientists, as it should be.  The recent case of Sylvain Lesné is one of the more spectacular examples.  We have discussed this previously.  Dr. Lesné published a […]

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