Category Archives: Science and the scientific method

Coffee Break: More on American Science, An NIH Grant Long Overdue, An Experimental Model, and Further Thoughts on AI

Part the First: Back to the Past in Science and Medicine.  The future of basic science in the United States looks grim for everyone from the aspiring graduate student to the full professor who has met her potential and has several graduate students, postdocs, and technicians working in her laboratory.  The precipitous and arbitrary Big […]

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A New Cancer Drug and the Nature of Scientific Discovery

Glen Campbell, who was a member of The Wrecking Crew, once remarked that he had worked hard for ten years to become an overnight success in 1967, with thanks to John Hartford.  Without stretching too much, this same trajectory, extended by more than ten years, has been illustrated recently in biomedical research by the case […]

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Coffee Break: Ancient Art, the Return of Analog, Science in Distress, and Death Is for Losers

Part the First: Functional Art from the Enigmatic Daunians.  William Morris famously wrote, “Have nothing in your houses that you do not know to be useful or believe to be beautiful.”  Of course, his beauty in response to the immiseration of the working class was for the English rich but nothing is perfect.  Our old […]

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Coffee Break: American Science in the Crosshairs, Nuclear Nightmares, and a Vision of a Good Life

Part the First: The Attack on American Science Continues, Unabated.  A few days ago the president fired the National Science Board (NSB), all twenty-two members of a statutory twenty-five, who served staggered six-year terms that preserved institutional memory.  The NSB was created pursuant to the National Science Foundation Act of 1950 to “recommend and encourage […]

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Coffee Break: Alzheimer’s Disease Still a Mystery and Books Worth Reading

Part the First: Anti-amyloid Antibodies and Alzheimer’s Disease (AD).  A Cochrane review of monoclonal antibodies targeting amyloid plaques in AD has found that these drugs have little to no effect on cognitive function of AD patients.  Cochrane reviews are, to use one of the favorite tropes of the current administration, considered the “gold standard” of […]

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Coffee Break: Scientists Being Bad and Good, the Moon, and More Ancient Archaeology

Part the First: Dealing with Scientific Misconduct.  Trust in science has declined during my professional work life.  Some, but not all, of this is due to misconduct by scientists, as it should be.  The recent case of Sylvain Lesné is one of the more spectacular examples.  We have discussed this previously.  Dr. Lesné published a […]

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Coffee Break: All War All the Time, AI on the Loose, and Hope for Muscular Dystrophy Patients

Part the First: War Begets War, A Conversation.  Daedalus hosted a conversation among Robert Jay Lifton (1926-2025), Neta C. Crawford, and  Matthew Evangelista last year.  It was preprinted recently in The MIT Press Reader.  I immediately noticed the participation of Robert Jay Lifton.  Back in my dark ages, when the university had a University Bookstore […]

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